Synthesis, characterization, antimicrobial and cytotoxicity studies of a novel titanium dodecylamino phosphate

Add time:07/11/2019    Source:sciencedirect.com

A novel titanium dodecylamino phosphate has been synthesized instantly at ambient temperature and characterized by various analytical and spectroscopic techniques such as PXRD, SEM-EDAX, TGA/DTA, FT-IR, dispersive Raman, UV–Vis DRS, XPS, 31P and 13C MAS NMR. The material was tested for biological activities such as antimicrobial, nematicidal and anticancer. The material exhibits potent antimicrobial activity against Gram-positive bacteria and fungi. The percentage mortality against Meloidogyne incognita nematode was increased with increase in concentration and incubation time. Further the material was also investigated for anticancer on human cancer cell lines such as cervix (HeLa), leukemia (HL60) and breast (MCF7). The cells were dosed with varying concentrations of the material and cell viability was measured by sulforhodamine-B (SRB) calorimetric assay. Interestingly, the material shows GI50 values of 39.8 μg mL−1 (HL60), 13.2 μg mL−1 (MCF7) and a superior value of 10.6 μg mL−1 (HeLa), respectively. However the material was found to be excellent and active against HeLa and MCF7 than HL60 cells leading to the conclusion that presence of titanium and amino groups were responsible for cytotoxicity.

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