Synthesis, characterization, antimicrobial and cytotoxic studies of a novel vanadium dodecylamino phosphate

Add time:07/12/2019    Source:sciencedirect.com

A novel vanadium dodecylamino phosphate was synthesized by mixing phosphoric acid and vanadyl acetylacetonate with dodecylamine at ambient temperature. The material was characterized by various spectroscopic and analytical techniques to know its morphological and structural characteristics. The biological activity of the material toward antimicrobial, nematicidal, DNA cleavage and cytotoxicity has been screened. The material exhibits moderate to good antimicrobial activity against Gram-positive bacteria. The percentage mortality on Meloidogyne incognita nematode was found to increase with increase in concentration of VDDAP at 48 h. Further, the material was investigated for cytotoxicity on human cancer cell lines such as cervix (HeLa), leukemia (HL60) and breast (MCF7). The cells were dosed with varying concentrations of the VDDAP and cell viability was measured by sulforhodamine B (SRB) assay to determine their GI50 values. Interestingly, the compound shows GI50 values of 25.4 μg mL−1 (HeLa), 29.1 μg mL−1 (MCF7) and a superior value of 11.6 μg mL−1 (HL60) respectively. The DNA cleavage activity of the material was investigated using agarose gel electrophoresis.

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