Development of terbium-sensitized fluorescence method for the determination of alendronate in biological samples followed by magnetic solid-phase extraction

Add time:07/30/2019    Source:sciencedirect.com

A new method based on combining terbium-sensitized fluorescence method and magnetic solid-phase extraction (MSPE) was developed for the quantification of alendronate (ALD) in biological samples. The fluorescence intensity of Tb3+-ALD complex was measured at 545 nm following elution from polymer coated magnetic nanoparticles surface. MNPs modified with PEG-b-P(IA-co-DMAEMA) block copolymer were synthesized and the effects of various parameters on MSPE efficiency and the fluorescence intensity were investigated. The dynamic assay range for ALD determination was obtained (0.04 to 0.8 mg/L) with a quantification limit of 0.033 mg/L. The accuracy of recovery, reproducibility, and sensitivity of the developed method suggested that it can be feasibly developed to a platform for monitoring the ALD concentration in human urine and plasma samples.

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