Nucleosides and nucleotides. 171. Thermal and nuclease stabilities of G-quadruplexes consisting of oligodeoxynucleotides containing 5-[N-[2-[N,N-bis(2-amino-ethyl)amino]ethyl]carbamoyl]-2′-deoxyuridine or 5-[N-[3-[N,N-bis(3-aminopropyl)amino]propyl]carbamoyl]-2′-deoxyuridine
-
Add time:07/31/2019 Source:sciencedirect.com
The thermal and nuclease stabilities of G-quadruplexes consisting of oligodeoxynucleotides (ODNs) containing 5-[N-[2-[N,N-bis(2-aminoethyl)amino]ethyl]carbamoyl]-2′-deoxyuridine (BAE) or 5-[N-[3-[N,N-bis(3-aminopropyl)amino]propyl]carbamoyl]-2′-deoxyuridine (BAP) are described. We found that the modified nucleosides, BAE and BAP, stabilize quadruplex formation when positioned at the 3′-end of the ODN. Furthermore, ODNs containing the modified nucleosides were more resistant to nucleolytic hydrolysis by snake venom phosphodiesterase than an unmodified ODN.
We also recommend Trading Suppliers and Manufacturers of 5-ETHYL-2'-DEOXYURIDINE (cas 15176-29-1). Pls Click Website Link as below: cas 15176-29-1 suppliers
Prev:An improved synthesis of 14C-labelled 2,2′-anhydrouridine, 2′-deoxyuridine and 5-ethyl-2′-deoxyuridine
Next:Deoxyribosyl exchange reactions leading to the in vivo generation and regeneration of the antiviral agents (E)-5-(2-bromovinyl)-2′-deoxyuridine, 5-ethyl-2′-deoxyuridine and 5-(2-chloroethyl)-2′-deoxyuridine) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Synthesis of [2-14C]-labelled 2,2′-anhydrouridine and 2'-deoxyuridine derivatives. A convenient route to [2-14C]-labelled 5-ethynyl- and 5-ethyl-2′-deoxyuridine08/05/2019
- 5-ethyl-2′-deoxyuridine: An explanation for its lack of cytotoxic action in Vivo08/04/2019
- 5-Ethyl-2′-deoxyuridine-5′-monophosphate inhibition of the thymidylate synthetase from escherichia coli08/03/2019
- Structure of the major metabolite of 5-ethyl-2′-deoxyuridine in rats08/02/2019
- Deoxyribosyl exchange reactions leading to the in vivo generation and regeneration of the antiviral agents (E)-5-(2-bromovinyl)-2′-deoxyuridine, 5-ethyl-2′-deoxyuridine and 5-(2-chloroethyl)-2′-deoxyuridine08/01/2019
- An improved synthesis of 14C-labelled 2,2′-anhydrouridine, 2′-deoxyuridine and 5-ethyl-2′-deoxyuridine07/30/2019
- Synthesis, biotransformation, pharmacokinetics, and antiviral properties of 5-ethyl-5-halo-6-methoxy-5,6-dihydro-2′-deoxyuridine diastereomers07/29/2019
- Synthesis of tricarbonyl rhenium and technetium complexes of a 5′-carboxamide 5-ethyl-2′-deoxyuridine for selective inhibition of herpes simplex virus thymidine kinase 107/28/2019
- Bioavailability and pharmacokinetic parameters for 5-ethyl-2′-deoxyuridine07/27/2019
