5-Ethyl-2′-deoxyuridine-5′-monophosphate inhibition of the thymidylate synthetase from escherichia coli
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Add time:08/03/2019 Source:sciencedirect.com
The synthesis of 5-ethyl-2′-deoxyuridine-5-monophosphate (EtdUrdMP) and an improved method for the purification of deoxythymidylate synthetase (TdRMP synthetase) from E. coli are described. TdRMP synthetase was inhibited competitively by EtdUrdMP (K1 = 2·2 × 10−5 M). Under similar conditions the Ki for deoxythymidine monophosphate (TdRMP) was 2·0 × 10−5 M. The possible role of EtdUrdMP in the virostatic activity of the nucleoside 5-ethyl-2′-deoxyuridine (EtdUrd) is considered.
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