Ouabain-uninhibited Na+ transport in human erythrocytes: the effects of Triflocin (cas 13422-16-7)

Add time:07/27/2019    Source:sciencedirect.com

1.1. Triflocin, a new diuretic agent, was used to study ouabain-uninhibited Na+ transport in human erythrocytes.2.2. Triflocin inhibits ouabain-uninhibited 22Na+ efflux and 22Na+ influx and in this regard it resembles furosemide and ethacrynic acid. No effect on net Na+ flux could be demonstrated.3.3. The portion of the ouabain uninhibited 22Na+ flux inhibited by triflocin, ethacryanic acid or furosemide appears to represent exchange diffusion Na+ rather than a net transport step.

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