Efficient synthesis of tetrazole derivatives of Cytisine (cas 15191-27-2) using the azido-Ugi reaction
-
Add time:07/28/2019 Source:sciencedirect.com
The azido-Ugi reaction with natural alkaloid Cytisine (cas 15191-27-2) was investigated. It was demonstrated that the reaction could be performed with various carbonyls (both aldehydes and ketones) and isocyanides. The transformation proceeded under mild conditions in methanol using TMSN3 as a source of hydrazoic acid to give target tetrazole derivatives of cytisine in up to 98% yield. The diastereoselectivity of this reaction was studied using both aliphatic and aromatic aldehydes. A family of tetrazole derived cytisine compounds was prepared. Selective deprotection of tetrazoles was elaborated to synthesize the corresponding NH-tetrazoles.
We also recommend Trading Suppliers and Manufacturers of Cytisine (cas 15191-27-2). Pls Click Website Link as below: cas 15191-27-2 suppliers
Prev:Spectral and photophysical properties of Cytisine (cas 15191-27-2) in acetonitrile – Theory and experiment
Next:Novel Cytisine (cas 15191-27-2) derivatives exert anti-liver fibrosis effect via PI3K/Akt/Smad pathway) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Synthesis and evaluation of camphor and Cytisine (cas 15191-27-2)-based cyanopyrrolidines as DPP-IV inhibitors for the treatment of type 2 diabetes mellitus08/04/2019
- Cytisine (cas 15191-27-2) basicity, solvation, log P, and log D theoretical determination as tool for bioavailability prediction08/03/2019
- Designing and preparation of Cytisine (cas 15191-27-2) alkaloid surface-imprinted material and its molecular recognition characteristics08/02/2019
- Luminescent characterization of interaction efficiency between (−)-Cytisine (cas 15191-27-2) and amino acids an indicator of anti-inflammatory of some 12-N-substituted (−)-Cytisine (cas 15191-27-2) derivatives08/01/2019
- Agonist and antagonist effects of Cytisine (cas 15191-27-2) in vivo07/31/2019
- Unlocking Nicotinic Selectivity via Direct C‒H Functionalization of (−)-Cytisine (cas 15191-27-2)07/30/2019
- Novel Cytisine (cas 15191-27-2) derivatives exert anti-liver fibrosis effect via PI3K/Akt/Smad pathway07/29/2019
- Spectral and photophysical properties of Cytisine (cas 15191-27-2) in acetonitrile – Theory and experiment07/27/2019