Designing and preparation of Cytisine (cas 15191-27-2) alkaloid surface-imprinted material and its molecular recognition characteristics

Add time:08/02/2019    Source:sciencedirect.com

Based on molecular design, a Cytisine (cas 15191-27-2) surface-imprinted material was prepared using the new surface-imprinting technique of “pre-graft polymerizing and post-imprinting”. The graft-polymerization of glycidyl methacrylate (GMA) on the surfaces of micron-sized silica gel particles was first performed with a surface-initiating system, preparing the grafted particles PGMA/SiO2. Subsequently, a polymer reaction, the ring-opening reaction of the epoxy groups of the grafted PGMA, was conducted with sodium 2,4-diaminobenzene sulfonate (SAS) as reagent, resulting in the functional grafted particles SAS-PGMA/SiO2. The adsorption of cytisine on SAS-PGMA/SiO2 particles reached saturation via strong electrostatic interaction between the sulfonate groups of SAS-PGMA/SiO2 particles and the protonated N atoms in cytisine molecule. Finally, cytisine surface-imprinting was successfully carried out with glutaraldehyde as crosslinker, obtaining cytisine surface-imprinted material MIP-SASP/SiO2. The binding and recognition characteristics of MIP-SASP/SiO2 towards cytisine were investigated in depth. The experimental results show that there is strong electrostatic interaction between particles and cytisine molecules, and on this basis, cytisine surface-imprinting can be smoothly performed. The surface-imprinted MIP-SASP/SiO2 has special recognition selectivity and excellent binding affinity for cytisine, and the selectivity coefficients of MIP-SASP/SiO2 particles for cytisine relative to matrine and oxymatrine, which were used as two contrast alkaloids, are 9.5 and 6.5, respectively.

We also recommend Trading Suppliers and Manufacturers of Cytisine (cas 15191-27-2). Pls Click Website Link as below: cas 15191-27-2 suppliers

Prev:Luminescent characterization of interaction efficiency between (−)-Cytisine (cas 15191-27-2) and amino acids an indicator of anti-inflammatory of some 12-N-substituted (−)-Cytisine (cas 15191-27-2) derivatives
Next:Cytisine (cas 15191-27-2) basicity, solvation, log P, and log D theoretical determination as tool for bioavailability prediction)