Regio- and stereo-selective introduction of a bis(methoxycarbonyl)methyl group into the γ-position of the piperidine sketeton

Add time:07/11/2019    Source:sciencedirect.com

A new method for a regioselective introduction of a bis(methoxycarbonyl)-methyl group into the 4-position of the piperidine skeleton was explored, and this method was applied to the preparation of cis- and trans-2,4-disubstituted piperidines starting from 2-piperidinecarboxylic acid. The key steps in the method involved electrochemical oxidation of carbamates.

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