Enantioselective synthesis of α-hydroxy thioesters via oxazaborolidine-mediated reduction of α-phenylthio enones

Add time:07/13/2019    Source:sciencedirect.com

α-Phenylthio-α,β-alkenones (2), readily available by Pd(II)-catalysed coupling of (E)-1-phenylthio-1-tributylstannylhex-1-ene with the corresponding acid chlorides, have been treated with borane in the presence of phenylglycine- or proline-derived oxazaborolidines to afford 2-phenylthio-2-alken-1-ols (3) with good to excellent enantioselectivities. Ozonolysis of 3 provides a new and efficient route to chiral α-hydroxy thioesters 4.

We also recommend Trading Suppliers and Manufacturers of 1-[(PHENYLTHIO)METHYL]PIPERIDINE (cas 6631-82-9). Pls Click Website Link as below: cas 6631-82-9 suppliers

Prev:Preparation of α-substituted S-phenylthio esters from 2-nitro-2-phenylthio oxiranes
Next:5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine (WY-135), a novel ALK inhibitor, induces cell cycle arrest and apoptosis through inhibiting ALK and its downstream pathways in Karpas299 and H2228 cells)