Production of chromogranin A and B derived peptides in human small cell lung carcinoma cell lines

Add time:07/29/2019    Source:sciencedirect.com

Production of chromogranin (Cg)A and B derived peptides [pancreastatin (PST), GAWK, CCB] was studied using human lung carcinoma derived cell lines. PST-like immunoreactivity (LI) was detected in the culture medium in 3 of 6 small cell lung carcinoma (SCLC) cell lines, while GAWK- and CCB-LIs were detected in 5 of 6 and all the 6 SCLC cell lines, respectively. CCB-LI was produced in large amounts in SCLC cell lines as compared to PST- and GAWK-LIs. In non-SCLC cell lines, on the other hand, PST- and GAWK-LIs were not detected. CCB-LI was detected in 1 of 7 non-SCLC cell lines, but not detected in the remainder. PST, GAWK and CCB-LIs, secreted by these cell lines, consisted of several peaks, and these peaks were different among cell lines. This suggests that processing of CgA and B is different in the cell lines. Production of CgA and B derived peptides seems to be a characteristic feature of SCLC, and among them, CCB LI may be a useful marker for SCLC.

We also recommend Trading Suppliers and Manufacturers of CHROMOGRANIN A (272-288) (PORCINE) (cas 106507-61-3). Pls Click Website Link as below: cas 106507-61-3 suppliers

Prev:Pan-neuronal expression of chromogranin A in rat nervous system
Next:The Meinwald reaction of alkyl propionates. Synthesis of the C1–C9 fragment of aurisides)