The Meinwald reaction of alkyl propionates. Synthesis of the C1–C9 fragment of aurisides

Add time:07/28/2019    Source:sciencedirect.com

The C1–C9 northern fragment of aurisides 12a was prepared in eight steps and 41% overall yield starting from Grieco's bicyclic lactone (+)-4. The synthesis features a key stereoselective Meinwald reaction of the lithium enolate of alkyl propionate with the functionalized δ-lactone 3.

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