Application of organolithium and related reagents in synthesis. Part 7. Synthesis and metallion of 4-methoxypicolin- and 2-methoxyisonicotin-anilides. A useful method for preparation of 2, 3, 4-trisubstituted pyridines

Add time:07/28/2019    Source:sciencedirect.com

The synthesis and metallation of 4-methoxypicolin- and 2-methoxyisonicotin-anilides as a way of regiospecific transformation of picolinic and isonicotinic acids into 2, 3, 4-trisubstituted pyridines, is described. The resulted C3 - alkylated derivatives underwent smooth acid - catalysed conversion into the corresponding pyridones.

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