Organosilicon based synthesis of new functionalized aminomethylenediphosphonates with moieties of amino acids
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Add time:07/30/2019 Source:sciencedirect.com
The new functionalized aminomethylenediphosphonates with moieties of various amino acids are synthesized via unique reaction of tris(trimethylsilyl) phosphite and N-formyl amino acids at the presence of effective catalyst – trimethylsilyl triflate under mild conditions. The further treatment of aminomethylenediphosphonates with the methanol excess resulted in the water-soluble functionalized aminomethylenediphosphonic acids.
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