Antibacterial and Antifungal Properties of β-Naphthol Derivatives IV*

Add time:07/29/2019    Source:sciencedirect.com

The bacteriostatic and fungistatic activities of a number of β-naphthol and 2-hydroxy-3-naphthoic acid derivatives are reported against Bacillus typhosus, Micrococcus pyogenes, var. aureus, and Aspergillus niger. Selected compounds from the initial screening were further tested for their activity against Bacillus paratyphosus A, Bacillus coli, Bacillus dysenteriae Shiga, Micrococcus pyogenes, var. albus, Streptococcus-β-haemolyticus, Clostridium tetani, Epidermophyton floccosum, Trichophyton rubrum, and Trichophyton gypseum. Few compounds exhibit activity against Gram-negative organisms at concentrations below 50 μg/cc., and none against C. tetani. The bacteriostatic concentration for Gram-positive organisms of 3,6-dibromo-, 3,4′,6-tribromo-, 6-n-pentyl-, and 6-n-hexyl-β-naphthols and 1,4-dibromo-, 1,6-dibromo-, and 1,4,6-tribromo-2-hydroxy-3-naphthanilides is between 0.2 and 10 μg./cc. Marked inhibition of all the fungous pathogens was shown by 6,6′-dibromo-β-dinaphthol and 1-bromo-β-naphthol. 3-Chloro-, 1-bromo-, 6-bromo-, and 1,6-dinitro-naphthols inhibited the growth of E. floccosum and T. rubrum at concentrations ranging between 1 and 10 μg/cc.

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