Structure and activity in chemical carcinogenesis

Add time:07/31/2019    Source:sciencedirect.com

7-Bromomethylbenz[a]anthracene was less carcinogenic than the parent hydrocarbon, 7-methylbenz[a]anthracene, whereas 7-bromomethyl-12-methylbenz[a]anthracene was a potent carcinogen, giving 100% incidence of sarcoma in the rat after a single subcutaneous injection. The chemical reactivities of these two bromo-compounds were compared, and the more carcinogenic compound was shown to react more rapidly, and also to a greater extent through a first order process.

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