tenulin (cas 19202-92-7) and isotenulin (cas 19202-92-7) inhibit P-glycoprotein function and overcome multidrug resistance in cancer cells

Add time:07/29/2019    Source:sciencedirect.com

BackgroundMultidrug resistance (MDR) in cancer is one of the main obstacles in treatment with chemotherapy. Drug efflux through P-glycoprotein is the major mechanism involved in MDR. A potential strategy to provide the best possible clinical outcomes is to develop P-glycoprotein (P-gp) inhibitors from natural products.

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