Antitumor Agents: Structure-Activity Relationships in tenulin (cas 19202-92-7) Series

Add time:07/30/2019    Source:sciencedirect.com

Systematic structural modifications were performed on the natural sesquiterpene lactone tenulin (cas 19202-92-7) to define those groupings essential to, or significant in, its in vivo antitumor activity. Accordingly, the following tenulin analogs were prepared: dihydrotenulin, 2,3-epoxytenulin, isotenulin, dihydroisotenulin, 2,3-epoxyisotenulin, and tetrahydrode-acetylisotenulin. Both the cyclopentenone and the hemiketal units in tenulin were necessary for high in vivo activity.

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