Polyfluoroaralkylamines: an improved synthesis of 4,5,6,7-TETRAFLUOROINDOLE (cas 16264-67-8)

Add time:07/29/2019    Source:sciencedirect.com

Tetrafluoroindole (5), a precursor for potential biologically-active compounds, was prepared previously in a four-step synthesis from C6F6. However, catalytic reduction of pentafluorophenylacetonitrile (2) to 2-pentafluorophenylethyl amine (3) is accompanied by a significant amount of a secondary amine, which, like 3, undergoes cyclization to an indoline and subsequent dehydrogenation to a new indole 8. The side-reaction in the reduction of 2 to 3 is obviated by the use of LiAlH4AlCl3 (1:1). The final aromatization to yield 5 is vastly improved by replacing MnO2 with DDQ.

We also recommend Trading Suppliers and Manufacturers of 4,5,6,7-TETRAFLUOROINDOLE (cas 16264-67-8). Pls Click Website Link as below: cas 16264-67-8 suppliers

Prev:In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells
Next:Selenium dioxide oxidation of 3-methyl-4,5,6,7-TETRAFLUOROINDOLE (cas 16264-67-8)s: an efficient route to tetrafluoro analogs of 3-formyl and 3-acetoxymethylindole systems)