Synthesis, characterization and antibacterial activity of novel heterocyclic quaternary ammonium surfactants

Add time:08/01/2019    Source:sciencedirect.com

This work reports two new classes of non-toxic heterocyclic quaternary ammonium surfactants (HQASs) synthesized by condensation of a series of fatty acids with 2-morpholinoethan-1-amine and pyridin-4-ylmethanamine, followed by quaternization with benzyl bromide. Their critical micelle concentration (CMC), Krafft temperature (Tk), emulsion stability and foaming properties were determined. The CMC values of HQASs ranged from 0.24 to 0.55 mM/L. In vitro antibacterial activity studies revealed that the HQASs possessing unsaturated hydrocarbon chains exhibited activity against all the tested bacteria (minimum inhibitory concentration = 31.25–500 μg/mL) whereas, those possessing saturated hydrocarbon chains did not exhibit any activity.

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