Metabolism of 2-chloro-N-isopropylacetanilide in chickens

Add time:07/31/2019    Source:sciencedirect.com

2-Chloro-N-isopropylacetanilide was quantitatively metabolized in chickens in the mercapturic acid pathway (MAP). The MAP metabolites (cysteine conjugate, S-carboxymethyl-N-acetyl cysteine, N-acetyl cysteine conjugate, and N-acetyl cysteine sulfoxide conjugate) were excreted mainly with the urine with minor amounts (less than 7% of the dose) excreted with bile. The cysteine conjugate was precursor for all the MAP metabolites, as well as, for N-isopropyloxanilic acid and N-isopropylacetanilide. Cysteine conjugate β-lyase activity was detected in the intestinal contents in vitro but was not manifested in vivo when the cysteine conjugate was injected intracecally.

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