Arg–Cys and Arg–cysteamine adsorbed on gold and the G-protein–adsorbate interaction

Add time:08/04/2019    Source:sciencedirect.com

The dipeptide, Arg–Cys, and the related molecule, Arg–cysteamine, are adsorbed to gold surfaces and the monolayers are characterized. Chemical binding and electronic structure of the monolayers are obtained by X-ray photoelectron spectroscopy (XPS). Strong molecular binding of the adsorbates to gold surface through the sulfur atom is attained. Orientation of the adsorbates on gold is studied using infrared reflection absorption spectroscopy (IRAS). Arg–Cys is interpreted to be adsorbed on gold in a compact configuration. The Arg–cysteamine molecule is adsorbed on gold with the main molecular axis perpendicular to the surface. Interaction of G-protein with the adsorbates was studied using the surface plasmon resonance (SPR) technique. It is believed that arginine has a major role in G-protein recognition since the G-protein-coupled receptor (GPCR) α2A has an arginine-rich region in the G-protein-binding part of the third intracellular loop.

We also recommend Trading Suppliers and Manufacturers of CYS-GLY (cas 19246-18-5). Pls Click Website Link as below: cas 19246-18-5 suppliers

Prev:Binding of Hg2+ by Cys, CYS-GLY (cas 19246-18-5) and reduced glutathione: Study by differential pulse voltammetry on rotating Au-disk electrode, electrospray ionization mass-spectrometry and isothermal titration calorimetry
Next:Enhanced oxygen tolerance of hydrogenase from Klebsiella oxytoca HP1 by Gly–Cys exchanges nearby Fe–S clusters as biocatalysts in biofuel cells or hydrogen production)