A one-pot approach to 4,5-dihydropyrazoles from ketones, arylacetylenes, and hydrazines

Add time:07/31/2019    Source:sciencedirect.com

An efficient and straightforward one-pot strategy for the synthesis of 4,5-dihydropyrazole derivatives from ketones, arylacetylenes, and hydrazines in the presence of KOtBu/DMSO is described. This strategy provides a flexible and rapid route to polysubstituted 4,5-dihydropyrazoles.

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