KMnO4-mediated direct C2-selective C−H arylation of quinoline N-oxides with aromatic hydrazines

Add time:08/01/2019    Source:sciencedirect.com

An efficient protocol for the synthesis of 2-arylquinoline N-oxides has been developed via KMnO4-mediated cross-coupling reaction of quinoline N-oxides with aromatic hydrazines in moderated to good yields. The reactions proceeded efficiently over a broad range of substrates with excellent regioselectivity and functional group tolerance.

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