Regioselective metallations of (methoxymethoxy)arenes

Add time:07/11/2019    Source:sciencedirect.com

The methoxymethoxy substituent when attached to an aromatic ring functions as a moderately strong ortho-directing group in hydrogen-metal exchange reactions. In many cases the propensity of the methoxymethoxylated arene toward ring metallation is greatly enhanced with concomitant suppression of undesirable side reactions such as nucleophilic attack and addition of the metallating species. Unlike many other ortho-directing groups, the regio-direction of the methoxymethoxy substituent when in conjunction with other weaker directing groups is dependent upon the metalating medium. Thus, by changing the electron donating capacity of the metallating medium it is possible to selectively direct metallation to either of the positions ortho to the methoxymethoxy substituent.

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