Monomorphism of cytidine (Cyd) vs. polymorphism of 2′deoxycytidine (dCyd). Structural and functional consequences

Add time:07/12/2019    Source:sciencedirect.com

It has been found that 2′deoxycytidine (dCyd) crystallizes in different forms, denoted dCyd A, dCyd B and dCyd C·H2O.In the crystal lattice of the newly discovered form dCydC·H2O there is a crystalline water molecule present. The monohydrate of dCydC, under suitable conditions (RT, over P2O5, 48h), undergoes transformation into the fully dehydrated form—dCydC anhydro. The whole process of de- and re-hydratation has been observed by FTIR-PAS spectroscopy.The nature of the differences and similarities between structural and functional properties of crystalline forms of 2′dCyd and Cyd molecules has been discussed.

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