Deoxycholic acid derived monophosphites as chiral ligands in the asymmetric Suzuki–Miyaura cross-coupling

Add time:08/01/2019    Source:sciencedirect.com

Biaryl phosphites derived from deoxycholic acid were used as chiral ligands in the asymmetric Suzuki–Miyaura cross-coupling of arylboronic acids with aryl bromides. Amongst the different reaction parameters, the role of the base emerged as being crucial for the outcome of the reaction: the choice of base, and its amount, allowed enantiomerically enriched biaryl derivatives to be obtained at 1% catalyst loading and with an L:Pd ratio of 1:1.

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