Phenethylamine Inhibitors of Partially Purified Rat and Human Pancreatic Lipase

Add time:08/02/2019    Source:sciencedirect.com

Methodology for the preparation of rat and human pancreatic lipase (EC 3.1.1.3) is described, which resulted in good yield of partially purified, stable enzyme useful for kinetic studies. Apparent Km values for the rat (6.5 mM) and human (3.5 mM) enzyme were determined with triolein as the substrate. Several compounds of the phenethylamine class were found to be inhibitors of both rat and human pancreatic lipase. The structural feature in the phenethylamine series tested, which appeared to be necessary for lipase inhibition, was a halo-genated substituent on the 3 or 4 position of the aromatic ring as in flu-tiorex, fenfluramine, iV-benzyl-CXβ-methoxy-3-(trifluoromethyl)phen-ethylamine (I), chlorphentermine and p-chloroamphetamine. A chloro group at the 2 position was ineffective (chlortermine). Alterations in the ethylamine portion of the molecule did not cause significant changes in the inhibitory properties of the active phenethylamines.

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