Synthesis and biological activity of diastereoisomeric octahydro-1H-indole-5,6,7-triols, analogues of castanospermine

Add time:08/02/2019    Source:sciencedirect.com

A straightforward stereoselective route towards (3aR,5R,6S,7R,7aR)- and (3aR,5R,6S,7R,7aR)-octahydro-1H-indole-5,6,7-triol, analogues of castanospermine, starting from the corresponding shikimic acid derivatives is described. The key transformations of this approach are the Overman rearrangement and ring-closing metathesis to form the diastereoisomeric cis-fused (5R,6S,7R)-octahydro-1H-indole-5,6,7-triols in good overall yields. Evaluation for in vitro cytotoxicity revealed for some prepared compounds significant antiproliferative activity and weak glycosidase inhibition.

We also recommend Trading Suppliers and Manufacturers of 4-(tert-butyldimethylsilyloxy)indole (cas 106792-40-9). Pls Click Website Link as below: cas 106792-40-9 suppliers

Prev:mivacurium (cas 106791-40-6) induce mast cell activation and pseudo-allergic reactions via MAS-related G protein coupled receptor-X2
Next:High quantum yield both in solution and solid state based on cyclohexyl modified triphenylamine derivatives for picric acid detection)