Synthesis, spectral, structural and biological studies of N-cyclohexyl-2-(2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9-ylidene)hydrazinecarbothioamide derivatives

Add time:08/04/2019    Source:sciencedirect.com

Potential antimicrobial activities of azabicyclic skeleton based N-cyclohexyl-2-(2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9-ylidene)hydrazinecarbothioamides (6–10) was synthesized. The newly synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR, HRMS and elemental analysis. The synthesized compound 6 was further compared by 2D NMR techniques (HOMOCOSY, NOESY and HSQC). The single crystal XRD study revealed that the compound 6 adopts a twin-chair conformation with equatorial orientation of the aryl groups. Antimicrobial activities have been carried out for compounds 6–10 against a panel of bacterial and fungal strains using Streptomycin and Amphotericin B as standards.

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