Identification of canine urinary metabolites of the antiprotozoal agent 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2-benzisoxazole

Add time:08/05/2019    Source:sciencedirect.com

Metabolite fractions from the urine of a dog dosed with 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2-benzisoxazole (MK-0436) were obtained by the use of high-performance liquid chromatography. These fractions were of suitable purity for structural elucidation. Data obtained by mass spectrometry and NMR spectroscopy allowed the identification of seven major metabolites of this drug. Biotransformation in each case involved hydroxylation (mono or di) of the hexahydrobenzisoxazole ring.

We also recommend Trading Suppliers and Manufacturers of 5-METHYL-1,2-BENZISOXAZOLE (cas 10531-77-8). Pls Click Website Link as below: cas 10531-77-8 suppliers

Prev:Urinary Metabolites of the Antiprotozoal Agent cis-3a,4,5,6,7,7a-Hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2-benzisoxazole in the Rat
Next:Urinary Metabolites of 3a,4,5,6,7,7a‐Hexahydro‐3‐(1‐methyl‐5‐nitro‐1H‐imidazol‐2‐yl)‐1,2‐benzisoxazole in the Dog)