Enantioselective Michael addition of diethyl cyanomethylphosphonate to chalcones using bifunctional cinchona-derived organocatalysts: synthesis of chiral precursors of α-substituted β-aminophosphonates

Add time:08/04/2019    Source:sciencedirect.com

An enantioselective Michael addition of diethyl cyanomethyl phosphonate to chalcones catalysed by bifunctional catalysts based on cinchona alkaloids has been developed, producing enantiomerically enriched cyanophosphonate precursors of α-substituted β-aminophosphonates.

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