Asymmetric synthesis of α-hydroxymethylphosphonates and phosphonic acids via hydrophosphonylation of aldehydes with chiral H-phosphonate

Add time:08/05/2019    Source:sciencedirect.com

Diastereoselective hydrophosphonylation of aldehydes with a chiral H-phosphonate is described. High asymmetric inductions were obtained using a readily available TADDOL auxiliary. Subsequent, racemization-free removal of the chiral auxiliary led to the desired α-hydroxyphosphonic acids in very good yields and high enantiomeric purity as the (R)-enantiomers.

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