Formulation and evaluation of gastric-floating controlled release tablets of Ginkgolides
-
Add time:08/04/2019 Source:sciencedirect.com
The present investigation was conducted to formulate and evaluate gastric-floating controlled release tablets of Ginkgolides. The target tablets were formulated by powder direct compression method combined with hydrophilic polymer, floating assistant agent, and effervescent substance. Formulations were evaluated for in vitro drug release, in vitro floating ability, and in vivo gastro-retentive behavior by gamma scintigraphy technique. The optimized formulations showed good instant and total duration floating properties, and extended drug release characteristic for 12 h. The release behaviors of the tablets were fitted to zero-order model in the coupled action of drug diffusion and matrix erosion mechanism. In vivo behaviors of the tablets were observed at different time intervals from the radiographic pictures of the healthy volunteers and the retention time in the stomach was about 8 h. Results indicated that gastric-floating tablets of the Ginkgolides had the potential for a good gastric residence time and the controlled drug release.
We also recommend Trading Suppliers and Manufacturers of Ginkgolide A (cas 15291-75-5). Pls Click Website Link as below: cas 15291-75-5 suppliers
Prev:Pharmacokinetics and tissue distribution of Ginkgolide A (cas 15291-75-5), ginkgolide B, and ginkgolide K after intravenous infusion of ginkgo diterpene lactones in a rat model
Next:Characterizations of the hydrolyzed products of Ginkgolide A (cas 15291-75-5) and ginkgolide B by liquid chromatography coupled with mass spectrometry) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Ginkgolide A (cas 15291-75-5) ameliorates non-alcoholic fatty liver diseases on high fat diet mice08/10/2019
- Ginkgolides-loaded soybean phospholipid-stabilized nanosuspension with improved storage stability and in vivo bioavailability08/09/2019
- Pharmacokinetics of the prototype and hydrolyzed carboxylic forms of ginkgolides A, B, and K administered as a ginkgo diterpene lactones meglumine injection in beagle dogs08/08/2019
- Ginkgolide B functions as a determinant constituent of Ginkgolides in alleviating lipopolysaccharide-induced lung injury08/07/2019
- Ginkgolide C reduced oleic acid-induced lipid accumulation in HepG2 cells08/06/2019
- Characterizations of the hydrolyzed products of Ginkgolide A (cas 15291-75-5) and ginkgolide B by liquid chromatography coupled with mass spectrometry08/05/2019
- Pharmacokinetics and tissue distribution of Ginkgolide A (cas 15291-75-5), ginkgolide B, and ginkgolide K after intravenous infusion of ginkgo diterpene lactones in a rat model08/03/2019
-
Health and Chemical more >
-
Related Products