A convenient method for the synthesis of 2-amino substituted aza-heterocycles from N,N′-disubstituted thioureas using TsCl/NaOH

Add time:08/10/2019    Source:sciencedirect.com

p-Toluenesulfonyl chloride (TsCl)/NaOH has been introduced as reagent combination for the synthesis of 2-amino-oxa- or 2-amino-thiazolidines from N-(2-hydroxyethyl)-thioureas, but its general application in heterocycle synthesis has not been investigated. In this paper the convenient and efficient synthesis of a variety of 2-amino-substituted 1-aza 3-(aza, oxo or thio) heterocycles of different substitution and ring sizes is described. The application of polymer-supported TsCl facilitates work-up and renders the reaction conditions very suitable for parallel or robot synthesis.

We also recommend Trading Suppliers and Manufacturers of 1-Phenyl-3-(2-hydroxyethyl)thiourea (cas 102-12-5). Pls Click Website Link as below: cas 102-12-5 suppliers

Prev:Hydrophilic platinum complexes of N-2-hydroxyethyl- and N,N-di(2-hydroxyethyl)-N′-benzoylthiourea ligands. Crystal and molecular structure of N,N-di(2-hydroxyethyl)-N′-benzoythiourea
Next:Synthesis and characterisation of mixed-ligand platinum(II)–sulfoxide complexes, [PtCl(DMSO)(L)], for potential use as chemotherapeutic agents (HL=N,N-dialkyl-N′-(3-R-benzoyl)thiourea))