Comparative metabolism of benzo[ƒ]quinoline by liver microsomes from brown bullheads and rats

Add time:08/04/2019    Source:sciencedirect.com

1. Liver microsomes from rats were considerably more active in metabolizing benzo[ƒ]quinoline (B ƒ Q) than those from brown bullheads (Ictalurus nebulosus).2. The main B ƒ Q metabolites formed by both rat and brown bullhead liver microsomes were qualitatively similar and included B ƒ Q-7,8-dihydrodiol, B ƒ Q-9,10-dihydrodiol, B ƒ Q-N-oxide, 7-hydroxy B ƒ Q, and 9-hydroxy B ƒ Q.3. The liver microsomes from control brown bullheads and rats metabolized B ƒ Q primarily at the 7,8-and 9,10-positions, respectively, whereas in the case of microsomes from 3-methylcholanthrene (3-MC)-treated rats or brown bullheads, the major site of metabolic attack was the 7,8-position.4. A 3-MC-type of cytochrome P-450 appears to be primarily responsible for the oxidation of B ƒ Q by control brown bullhead liver microsomes, whereas a phenobarbital-inducible type of cytochrome P-450 seems to be involved in the metabolism of B ƒ Q by control rat liver microsomes.

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