Hepatic DNA adduct formation in rats treated with benzo[f]quinoline

Add time:08/07/2019    Source:sciencedirect.com

The formation of hepatic DNA adducts in male Sprague-Dawley rats following i.p. administration of benzo[f]quinoline (BfQ) was examined using a 32P-post-labeling assay. BfQ exhibited a low binding (11–27 amol adducts/μg DNA) to liver DNA. Two BfQ-nucleoside adducts (one major and one minor) were detected. The BfQ-DNA adducts formed in vivo were chromatographically distinct from the adducts formed by the reaction of calf thymus DNA in vitro with BfQ-5,6-oxide, syn-7β, 8α-dihydroxy-9β, 10β-epoxy-7,8,9,10-tetrahydroBfQ, anti-9α, 10β-dihydroxy-7α, 8α-epoxy-7,8,9,10-tetrahydroBfQ, or anti-7β, 8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tetrahydroBfQ-N-oxide. These results suggest that the bay-region diol epoxide of BfQ, unlike the bay-region diol epoxide derivatives of polynuclear aromatic hydrocarbons, is not involved in the covalent binding of BfQ to DNA.

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