Androgen receptor protein binding properties and tissue distribution of 2-selena-a-nor-5α-androstan-17β-ol in the rat

Add time:08/08/2019    Source:sciencedirect.com

2-selena-A-nor-5α-androstan-17β-ol was studied in vitro and in vivo in the rat prostate gland. The data demonstrates the ability of this compound to selectively complex with the specific receptors of 5α-dihydrotestosfcerone (5α-DHT) in the cytosol and to be retained in the nuclei in an unaltered form. Studies with selenium-75 labeled material suggests that the uptake and localization is similar to endogenous 5α-dihydrotestosterone.

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