Crystal structure, cytotoxicity and biological activity of hydrogen bonded networks based on dimethyltin (IV) and bipodal ligands

Add time:08/06/2019    Source:sciencedirect.com

The supramolecular complexes (SC) of the type [Me2SnCl2L], L = 2,2′-bipyridine (2,2′-bpy), SC 1, 4,4′-bipyridine (4,4′-bpy), SC 2, and (1,10-phenanthroline), SC 3, have been synthesized and structurally characterized by elemental analysis, FT-IR, UV–Vis, 1H and 13C NMR spectra and X-ray single crystal. The X-ray data of SC 1 and SC 2 exhibited 1:1 stoichiometry for the dimethyltin dichloride: bipodal ligand. The structure of SC 1 extends along the a-axis in a parallel way forming 1D-chains via H-bonds while they further propagate creating 2D-network via extensive H-bonds. The extending structure of the SC 2 along the a-axis consists of parallel 1D-chains via H-bonds creating the A … A … A fashion. Molecular modeling studies of SC 3 indicated that Sn(IV) center acquires N2C2Cl2 octahedral geometry. The tested compounds SC 1, SC 2 and SC 3 were found to inhibit cell proliferation and induce high percent of apoptotic towards human breast adenocarcinoma (MCF7), liver carcinoma (HEPG2), colorectal carcinoma (HCT-116), cervical carcinoma (HELA) and prostate cancer (PC3) cell lines in vitro model within short times of treatment. The anti-Oxidant and anti-hemolytic assays employ that SC 1 exhibits moderate antioxidant activity as well as the most potent anti-hemolysis activities compared with ascorbic acid. The antimicrobial assessment has been also studied by disc diffusion method.

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