Enantioselective Diels-Alder reaction using chiral Lewis acid prepared from grignard reagent and a chiral 2-(2-p-toluenesulfonylamino)phenyl-4-phenyloxazoline

Add time:08/04/2019    Source:sciencedirect.com

Enantioselective Diels-Alder reaction was conducted successfully using a chiral magnesium complex prepared from Grignard reagent and a chiral 2-(2-p-toluenesulfonylamino)phenyl-4-phenyloxazoline derived from easily available D-phenylglycine as a chiral auxiliary. The endo-isomer was exclusively obtained with 91%ee from the reaction of 3-crotonoyl-1,3-oxazolidin-2-one and cyclopentadiene.

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