Synthesis of new platinum(IV) complexes through breaking disulfide bond; crystal structure determination, electrochemical, photoluminescence and DNA interaction investigation

Add time:08/07/2019    Source:sciencedirect.com

New platinum(IV) complexes containing N2S2 donor atoms were synthesized by the reactions of [Pt(p-MeC6H4)2(SMe2)2] and [PtCl2(DMSO)2] with 2,2′-dithiopyridine (dtp) in 1:1 M ratio. In these reactions, 2-mercaptopyridine (mpy) ligands were formed through the cleavage of the disulfide bond in 2,2′-dithiopyridine. The mpy ligands were coordinated to the platinum center via the nitrogen and sulfur atoms and the obtained platinum(IV) complexes exhibited octahedral geometry. The complexes were characterized by FT-IR, 1H NMR, UV–Vis, elemental analyses and conductometry. The crystal structure of the arylplatinum(IV) complex containing C2N2S2 donor atoms was determined by single crystal X-ray diffraction. The obtained molar conductance values revealed that the platinum(IV) complexes were nonelectrolytes. The interactions of the complexes with calf thymus DNA (CT-DNA) were investigated by absorption and fluorescence spectroscopy, cyclic voltammetry and viscometry methods. The intrinsic binding constants (Kb) of the complexes with CT-DNA, obtained from UV–Vis absorption data, were 9.60 × 104 M−1 and 11.56 × 104 M−1. Furthermore, the enthalpy and entropy of the interaction between the platinum(IV) complexes and CT-DNA were calculated. The obtained data revealed positive enthalpy and entropy changes indicating a hydrophobic interaction between these complexes and CT-DNA.

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