Biopharmaceutical Characterization of Ciprofloxacin HCl–Ferrous Sulfate Interaction

Add time:08/12/2019    Source:sciencedirect.com

ABSTRACTThe ciprofloxacin–iron interaction, resulting in a lower bioavailability, is well documented in vivo; however, a mechanistic explanation supported by experimental data of this interaction is missing. In the present study, ciprofloxacin hydrochloride (HCl) and ferrous sulfate interaction was simulated in vitro by performing solubility and dissolution studies in the reactive media containing ferrous sulfate. Characterization of the precipitate formed indicated its probable chemical structure as Fe(SO42−)2(Cl−)2(ciprofloxacin)2 × (H2O)n, where n is up to 12 molecules of water. The solubility of this complex in water was estimated to be approximately 2 mg/mL, being about 20‐fold lower than the solubility of ciprofloxacin HCl. The solubility of the complex was used as input parameter for an in silico modeling by GastroPlus™ and the resulting predicted plasma time curves were in good agreement with the in vivo data. These results strongly indicate that ciprofloxacin–iron interaction in vivo is caused by the formation of a low soluble complex. This interaction was also simulated by in vitro dissolution, in which a mini scale apparatus provided more biorelevant results than the standard dissolution apparatus, probably because the drug concentrations in the mini apparatus were higher and, thus, closer to the conditions encountered in vivo.

We also recommend Trading Suppliers and Manufacturers of Ferrous sulfate monohydrate (cas 13463-43-9). Pls Click Website Link as below: cas 13463-43-9 suppliers

Prev:Micro-Raman studies of hydrous ferrous sulfates and jarosites
Next:The attractive efficiency contributed by the in-situ reactivation of ferrous oxalate in heterogeneous Fenton process)