A convenient route to functionalized 3-amino-N-methylfuro[3,2-b]pyridine-2-carboxamides

Add time:08/07/2019    Source:sciencedirect.com

The synthesis of novel functionalized 3-amino-N-methylfuro[3,2-b]pyridine-2-carboxamides is described from cyanopyridine intermediates. Based on the difference in halogen reactivity, ethyl [(5-bromo-2-chloropyridin-3-yl)oxy]acetate was functionalized by a palladium-catalyzed reaction, before the cyclization to the desired furo[3,2-b]pyridines.

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