Mutagenicity of K-region oxides and imines of chrysene, benzo[c]phenanthrene and benzo[g]chrysene in Salmonella typhimurium

Add time:08/05/2019    Source:sciencedirect.com

The K-region oxides and imines of chrysene, benzo[c]phenanthrene and benzo[g]chrysene were investigated for mutagenicity in Salmonella typhimurium TA98 and TA100, using two different exposure media. All six compounds were mutagenic under all four experimental conditions. The imines were 17–3800 times more potent than the corresponding oxides. Omission of KCl (125 mM) from the exposure medium resulted in enhanced mutagenic effects. The enhancement was stronger in strain TA98 (3.1–5.2-fold) than in strain TA100 (1.3–2.5-fold), suggesting an influence on the bacteria rather than on the chemicals.

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