Three-component reaction for the C2-functionalization of 1-substituted imidazoles with acetylenic ketones and isocyanates

Add time:08/05/2019    Source:sciencedirect.com

An efficient method for the direct C2-amidation of 1-substituted imidazoles with acetylenic ketones and isocyanates is reported. This three-component procedure has the advantages of catalyst-free, operational simplicity, mild reaction conditions, and good to excellent yields.

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