Potentiating effect of (+)-sotalol and deoxysotalol (cas 16974-42-8) on prostaglandin-evoked contractions of the isolated rat uterus

Add time:08/05/2019    Source:sciencedirect.com

The effect of (+)-sotalol and deoxysotalol (cas 16974-42-8) on prostaglandin (PGF2a and 15-methyl PGF2α)-evoked contractions was studied using the isolated rat uterus. After control responses to prostaglandins had been obtained the uterus was exposed to the nutrient fluid containing 10 μg/ml of (+)-sotalol, deoxysotalol or (−)-sotalol. 30 min later the responses to prostaglandins were again recorded. Both (+)-sotalol and deoxysotalol potentiated PGF2α as well as 15-methyl PGF2α-induced contractions. (−)-Sotalol did not potentiate the PGF2α-evoked contractions of the isolated rat uterus. The possible clinical significance of the results is discussed.

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