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Add time:08/08/2019    Source:sciencedirect.com

R-(–)-1-(Benzofuran-2-yl)-2-propylaminopentane hydrochloride [(–)-BPAP], a highly potent enhancer of impulse propagation-mediated release of catecholamines and serotonin in the brain, and significantly increased the locomotor activity of normal rats at the doses of 0.3 and 1 mg/kg s.c. (P < 0.05), while l-DOPA (200 and 400 mg/kg i.p.) had no significant effect. The locomotor activity of rats simultaneously administered l-DOPA and (–)-BPAP was significantly higher than with (–)-BPAP alone (P < 0.05). In rats pretreated with reserpine (1 mg/kg i.v.), the hypolocomotion was significantly reversed by 400 mg/kg i.p. l-DOPA, or 1 or 3 mg/kg s.c. (–)-BPAP (P < 0.05). Furthermore, the combined administration of subthreshold doses of 200 mg/kg i.p. l-DOPA and 0.3 mg/kg s.c. (–)-BPAP highly potentiated the locomotor activity in the reserpine-pretreated rats. However, (–)-BPAP failed to reverse the hypolocomotion in rats pretreated with reserpine + α-methyl-dl-p-tyrosine. Thus, (–)-BPAP was demonstrated to possess the l-DOPA-sparing effect in normal and reserpine-pretreated rats.

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