Bile Acid Enhancement of Reserpine-Induced Blepharoptosis
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Add time:08/14/2019 Source:sciencedirect.com
A more rapid onset of blepharoptotic activity in mice as well as a significantly increased oral potency relative to reserpine base was noted for reserpine coprecipitates with deoxycholic, cholic, and lithocholic acids. Some enhancement of potency was seen for a reserpine–trihydroxycholane combination, while a reserpine-cholanic acid coprecipitate was about equivalent to reserpine base. The use of water-soluble reserpine acetate increases both the apparent relative potency and the duration of activity, while the relatively water-insoluble reserpine hydrochloride only increases the duration of reserpine-like activity.
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