Structure-activity relationships for solubility and wettability of a number of substituted barbituric acids

Add time:08/07/2019    Source:sciencedirect.com

Data taken from published work on the physical properties of substituted barbituric acids show that structure-activity relationships exist for the wetting and for the solubility of these powders. Wetting and solubility results of the powders do not fall in the same rank order; this is demonstrated by phenobarbitone which has a wettability intermediate between the barbituric acids with the hydrophilic four-carbon substituent and the hydrophobic five-carbon substituent (butobarbitone and pentobarbitone, respectively), but has a reported solubility lower than that of butobarbitone and pentobarbitone.Compensation analysis of the wetting data shows a strong correlation with the results aligned in the perceived rank order of wettability. The compensation temperature is ~ 298 K. A strong correlation exists for the enthalpy-Gibbs function plot for the solubility data, revealing a surprising ordering of the compounds in a manner unrelated to their rank order of solubility.

We also recommend Trading Suppliers and Manufacturers of 5-Ethyl-5-(1-methyl-2-butenyl)barbituric acid (cas 17013-35-3). Pls Click Website Link as below: cas 17013-35-3 suppliers

Prev:Convulsant, anticonvulsant and anaesthetic barbiturates. 5-Ethyl-5-(3′-methyl-but-2′-enyl)-barbituric acid and related compounds
Next:5-Isopropylbarbituric and 2-thiobarbituric acids: An experimental and computational study)