Spin Trapping of O-, C-, and S-Centered Radicals and Peroxynitrite by 2H-imidazole-1-oxides

Add time:08/06/2019    Source:sciencedirect.com

Spin trapping with 2H-imidazole-1-oxides (2,2,4-trimethyl-2H-imidazole-1-oxide (TMIO); 4-carboxy-2,2-dimethyl-2H-imidazole-1-oxide, potassium salt (CDMIO); 2,2-dimethyl-4-phenyl-2H-imidazole-1-oxide(DMPIO)) was studied. It was found that these compounds form spin adducts with different short lived free radicals, such as·OH,·CH3,·CH2OH, CH3(·CH)OH, C(CH3)3O·, HOCH2CH2S·, glutathionyl and cysteinyl radicals. 2H-imidazole-1-oxides did not trap superoxide radical. Therefore, the detection of OH and thiol radicals is not complicated by the presence of superoxide radical. It was shown that 2H-imidazole-1-oxides are effective scavengers of peroxynitrite forming the same spin adducts as with OH-radicals. Thus, TMIO, CDMIO and DMPIO can be used for spin trapping studies in chemical and biological systems.

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